Direct flights
from Des Moines (DSM)
to Chicago (ORD)

Weekly schedule for flights between Des Moines Intl (Des Moines, United States) and Chicago O'Hare Intl (Chicago, United States) operated by 1 airlines.
47 weekly flights operate on this route flying 299mi in 22h29min.
Expect $425 in average for a one-way ticket with the cheapest option at $0.